One of the world's most varied and productive ecosystems the region has always been of central importance for Cambodia's food supply. It proved capable of largely maintaining the Angkorean civilization, the largest pre-industrial settlement complex in world history. Directly and indirectly it affects the livelihood of large numbers of a predominantly rural population. Due to ineffective administration and widespread indifference towards environmental issues, the lake and its surrounding ecosystem is coming under increasing pressure from over-exploitation and habitat degradation, fragmentation, and loss. All Mekong riparian states have either announced or already implemented plans to increasingly exploit the river's hydroelectric potential. A succession of international facilities that dam the river's mainstream is likely to be the gravest danger yet for the entire Tonle Sap eco-region.

The largest freshwater lake in Southeast Asia, that contains an exceptional large variety of interconnected eco-regions with a high degree of biodiversity is a biodiversity hotspot and was designated as a UNESCO biosphere reserve in 1997